Therapeutic Levels of Recombinant Hirudin

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Efficiently Than Recombinant Hirudin

Background Although the indirect thrombin inhibitor heparin and the more potent direct inhibitor hirudin are useful in preventing thrombosis, a substantial opportunity remains for improving the thrombus selectivity of thrombin inhibitors. Methods and Results To explore the effect of targeting an antithrombin to the surface of a clot, we covalently linked recombinant hirudin to the Fab' (or IgG)...

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Gastrointestinal absorption of recombinant hirudin-2 in rats.

To investigate the absorption of recombinant hirudin-2 (rHV2) after oral administration to rats and its possible absorption mechanism, a series of experiments were carried out. The degradation of (125)I-rHV2 in the luminal contents and variant mucosal subcellular fractions, as well as the effect of degradation inhibition of some adjuvant was investigated. The bioavailability of rHV2, with or wi...

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The emergency use of recombinant hirudin in cardiopulmonary bypass. 1999.

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Recombinant hirudin in clinical practice: focus on lepirudin.

Clinical applications for recombinant hirudins have been investigated for the past 10 years. The first indication for which a hirudin-lepirudin-has been approved is treatment of heparin-induced thrombocytopenia (HIT). Also, the recently completed trials for use of lepirudin in unstable angina indicate a potentially new indication. This review describes pharmacology and clinical applications of ...

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ژورنال

عنوان ژورنال: Pathophysiology of Haemostasis and Thrombosis

سال: 1992

ISSN: 1424-8832,1424-8840

DOI: 10.1159/000216347